CODEINGIL
Codeine has been located being an endogenous compound, along with morphine, from the brains of nonhuman primates with depolarized neurons, indicating that codeine may perhaps function being a neurotransmitter or neuromodulator during the central anxious program.
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Also, no evidence indicates that CYP2D6 inhibition is beneficial in treating codeine dependence,[23] however the metabolism of codeine to morphine (and as a result further more metabolism to glucuronide morphine conjugates) does have an effect on the abuse opportunity of codeine.
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